INDIKASI NEURALGIN RX®

08.49

NEURALGIN RX
Methampyrone, Thiamine HCL, Pyridoxine HCL, Cyanocobalamin, Trimethylxanthine
Composition 
Each film coated caplet contains :
Methampyrone
Thiamine HCL
Pyridoxine HCL
Cyanocobalamin
Trimethylxanthine 
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500   mg
  50   mg
  10   mg
  10 mcg
  50   mg


Pharmacology
Methampyrone is a potent nonnacrcotic analgesic - antipyretic drug. It is a pyrazolon derivative with therapeutic efficacy equivalent to that of acetosal, the standard drug for the nonnarcotic analgesic - antipyretic class. It causes less gastric irritation than acetosal and does not produce the acid - base or metabolic effects of salicylate.
However, it has been implicated for many years to cause a high incidence of agranulocytosis. An epidemiologic study of international scale involving about 30 milion people had been especially designed to study this matter. 
The study was completed just recently and the results showed that methampyrone, in fact, accounted for only a very low incidence of agranulocytosis.
Trimethylxanthine is commonly added to an analgesic as an analgesic adjuvant. in a dose of 50 mg or more, trimethylxanthine has been shown to enhance the analgesic efficacy of acetosal and acetaminophen ; in this case methampyrone should not be an exception.

Indications 
Relief of mild to severe pain, such as headache especially tension headache, hyalgia, arthralgia, neuralgia, lumbago, toothache, menstrual pain, pain from cancer, biliary and renal colic, postpartum pain, postoperative pain.

Contraindications 
  1. Hypersensitivity to methampyrone and other nonsteroidal anti inflammatory drugs.
  2. Concomitant administration with chlorpromazine (may result in serious hypothermia).
Precautions
  1. Use with caution in : 








.   Peptic ulcer (active/history).
.   hemostatic defects (avoid) or anticoagulant therapy.
  severe liver disease.
.   pregnancy (not recommended) especially late pregnancy.
.   nursing mother (not recommended).
.   infants.
.   history of blood dyscrasia.





     2.  Discontinyye the drug if the following develops :
  • fever, sore throat or stomatitis (may indicate agranulocytosis, hematologic evaluation shourd be performed)
  • evidence of peptic ulceration or gastrointestinal bleeding.               
Adverse Reactions 
The most frequent are gastrointestinal symptoms, such as nausea, vomiting, epigastric discomfort etc
Neuralgin Rx may also cause hypersensitivity reactions, e.g skin rashes and pruritus. Side effects occuring rarely are gastrointestinal bleeding and ulceration, leukopenia and agranulocytosis.

Dosage 
adults
Children    
:   1    - 2 caplets  3 to 4 times daily
:   1/2 - 1 caplet   3 to  4 times daily 
If gastrointestinal discomfort occurs, administer NEURALGIN Rx with or after meals.

Presentation 
Box of 10 strips x 10 film coated caplets.

Store below 30 Celcius

ON MEDICAL PRESCRIPTION ONLY.
HARUS DENGAN RESEP DOKTER.

Manufactured by :
PT KALBE FARMA Tbk.
Bekasi - Indonesia 

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